Tuesday, August 3, 2010

Animal for experimentation



Use of animals for experiments are widely used to develop new medicines and to test the safety of other products. Many of these experiments cause pain to the animals involved or reduce their quality of life in other ways. It is morally wrong to cause animals to suffer when using them for an experiment. This produced serious moral problems. It has been agreed that it is wrong to use animals if alternative testing methods would produce equally valid results. Experimentation on animals can either be accepted or rejected. It can be only accepted if the experimentation on the animal has a minimized level of suffering on the animals and only if and only if human benefits are gained which could not be obtained by using other methods. On the other hand, experimentation on animals can be kicked against if it causes suffering to the animals, if the benefits to human beings are not proven and also if any benefits to human beings and animal testing could be produced in other ways. Animal research has had a vital role in many scientific and medical advances of the past century and continues to aid our understanding of various diseases. Throughout the world, people enjoy a better quality of life because of these advances, and the subsequent development of new medicines and treatments. All these are made possible by animal research. However, the use of animals in scientific and medical research has been a subject of heated debate for many years in the UK. Opponents to any kind of animal research, including both animal-rights extremists and anti-vivisectionist groups, believed that animal experimentation is cruel and unnecessary, regardless of its purpose or benefit. There is no middle ground for these groups; they want the immediate and total abolition of all animal research. If they succeed, it would have enormous and severe consequences for scientific research.
Different moralists has given different reasons as to why cruelty to animals is wrong. Animal experimentation to some extent has not been fully accepted because, whether the reason is an essential right of the animal, or a reflex bad effect upon the character of the human being, or whatever it be, cruelty and needless infliction of suffering upon any sentient creature, is unquestionably wrong. There is however, no ethical justification for the assumption that experimentation upon animals, is not cruel even if the animal is under the influence of anæsthetics. There is equally no moral justification for the statement that the relations of scientific men to animals should be under any laws or restrictions save those general ones which regulate the behaviour of all men so as to protect animals from cruelty. The moral principles relating to animal experimentation can be stated positively as follows:
1. Scientist are under definite obligation to experiment upon animals  as long as that is the alternative to random and possibly harmful experimentation upon human beings, and if such experimentation is a means of saving human life and of increasing human vigor and efficiency.
2. The community at large is under definite obligations to see  that physicians and scientist are not needlessly hampered in carrying on the inquiries necessary for an adequate performance of their important social office of sustaining human life and vigor.
Moral right of competent persons on animal experimentation in order to get knowledge and resources needed to eliminate useless and harmful experimentation upon human beings and take better care of their health was understated. This type of experiment is more than a right but rather a duty.  When men have devoted themselves to the promotion of human health and vigor, they are under an obligation, to avail themselves of all the resources which will secure a more effective performance of their high office. This office is nothing more than the mere lessening of the physical pain endured by human beings when ill. Important as this is, there is something much worse than physical pain, just as there are better things than physical pleasures.
The person who is ill does not only suffer pain but is also rendered unfit to meet his ordinary social responsibilities. He is incapacitated for service to those about him and some of whom may be directly dependent upon him. Moreover, his removal from the sphere of social relations does not merely leave a blank where he was; it involves a wrench upon the sympathies and affections of others. The moral suffering thus caused is something that has no counterpart anywhere in the life of animals, whose joys and sufferings remain upon a physical plane. To cure disease, to prevent needless death, is thus a totally different matter, occupying an infinitely higher plane, from the mere palliation of physical pain. To cure disease and prevent death is to promote the fundamental conditions of social welfare. To secure the conditions requisite to an effective performance of all social activities, is to preserve human affections from the frightful waste and drain occasioned by the needless suffering and death of others with whom one is bound up. These things are so obvious that it almost seems necessary to apologize for mentioning them. But anyone who reads the literature or who hears the speeches directed against animal experimentation will recognize that the ethical basis of the agitation against it is due to ignoring these considerations. It is constantly assumed that the object of animal experimentation is a selfish willingness to inflict physical pain upon others simply to save physical pain to ourselves.
On the moral side, the whole question is argued as if it were merely a balancing of physical pain to human beings and to animals over against each other. If this is the case,  majority would probably decide that the claims of human suffering take priority over that of animals. But a minority would doubtless voice the opposite view, and the issue would be inconclusive; anyway this is not the question. Instead of being the question of animal physical pain against human physical pain, it is the question of a certain amount of physical suffering to animals, reduced to some extent to a minimum by the administration of anæsthesia, asepsis, and skill; against the bonds and relations which hold people together in society, against the conditions of social vigor and vitality, against the deepest of shocks and interferences to human love and service. No one who has faced this issue can be in doubt as to where the moral right and wrong lie. To prefer the claims of the physical sensations of animals to the prevention of death and the cure of disease, probably the greatest sources of poverty, distress and  inefficiency, certainly the greatest sources of moral suffering does not rise even to the level of sentimentalism. Scientists are given the right to use animal experimentation as an instrument in the promotion of social well-being, and at the same time, it is the duty of the general public to protect these men from attacks that hamper their work. It is the duty of the general public to sustain them in their endeavours. For physicians and scientist, they both have their individual shortcomings like the rest of us, though they are still acting as ministers and ambassadors of the public good.



Animal experimentation has laws which regulates it. They are explained below:
The first law, written specifically to regulate animal experimentation was Great Britain's 1876 Cruelty to Animals Act. This act was a much weakened version of the original, extremely bill, which came close to passage in 1875. The 1876 law, which implicitly approved animal experimentation at the same time that it set up a system of licensing and certification, was replaced by the Animals (Scientific Procedures) Act of 1986, which specifically states that "The Secretary of State shall not grant a project license until he is satisfied that the applicant has given adequate consideration to the feasibility of achieving the purpose of the programme to be specified in the license by means not involving the use of protected animals" (Animal Welfare, UFAW, Vol. 1, No. 2, 1992).
In the United States, the 1966 Animal Welfare Act, amended in 1970, 1976, 1986, 1989, and 1991, set standards for the transportation and husbandry of laboratory animals, excluding rats, mice, and birds. On January 8, 1992 the U.S. District Court in Washington, DC ruled that the U.S. Department of Agriculture had been violating the Animal Welfare Act by not enforcing its provisions as they relate to these animals. The U.S. Public Health Service Guide for the Care and Use of Laboratory Animals and the Health Research Extension Act of 1985 regulate all research funded by the National Institutes of Health (NIH) and require the submission of regular reports on protocols involving animals. The guide has been revised five times and is being updated once again this year. The NIH also requires accreditation by the American Association of Laboratory Animal Care (AAALAC) or the operation of an institutional animal care and use committee. However, since AAALAC requires an animal care and use committee as well, almost all institutions conducting vertebrate research or testing are now subject to review.


References:

  J MessickA Brief Examination of the Ethics of Animal Experimentation, Obtained from http://www.booksie.com/non-fiction/essay/jmessick/a-brief-examination-of-the-ethics-of-animal-experimentation, Accessed on 31st July, 2010.

 Joanne Zurlo, Deborah Rudacille, And Alan M. Goldberg, Animals And Alternatives In Testing: History, Science, And Ethics http://caat.jhsph.edu/publications/animal_alternatives/chapter5.htm, Accessed on 1st August, 2010.

John Dewey, The Ethics of Animal Experimentation obtained from http://www.bbc.co.uk/ethics/animals/using/experiments_1.shtml,Accessed on 2nd August,2010.


Group members:
Glory Benedict Bassey, 1000716427              


Food Wastage Reduction During the Food Processing Process

By Group 1 (Food Science & Nutrition)

           Food processing industry is the most huge industry in the world. The major sectors are fruit and vegetable, dairy food, meats and fish, alcoholic, beverages, oil as well as packaged foods.This processing industry gives an advantage towards people in terms of food production but proper management should be done especially on the wastage production. This is the most common problem which they have to face because the environmental issues arise due to the water consumption and water waste discharge, chemical used, packaging reduction and disposal and food scraps. These factors could lead to greenhouse gas emission and could house the disease causing microorganisms.There are many afforts that could be done in order to avoid these problems. These include process measurements and controls during the food processing , water conservation, dry cleaning, the use of less hazardous chemicals and the most recommended is by recycling of waste materials such as pulp of fruits and the juice extracts.

      Food Wastage Reduction in Pineapple and Orange Processing Process


         Talking about recycling of waste materials, this also includes recycling the pineapple and orange waste during the production of products like tarts and juices in the food production industries. The wastage from food production based on pineapple and orange are dumped carelessly after extracting the edible portion. So, researches have come up with new ways to overcome this by using the waste of pineapple and orange fruits act as a substrate in the fungal production of citric acid by using fungus such as Aspergillus niger.

         The citric acid can be used in the food and beverage industry to flavor fruit juices, candy, ice cream, and marmalade. Moreover, the citric acid used in the pharmaceutical industry can act as the preservatives for storing blood, tablets, ointments and cosmetics preparation. As for chemical industry, citric acid is one of the ingredients in the antifoam agent and for the treatment of textiles.

          So, many ways can be conducted by each industrial manager to achieve correlation between food production and maintaining the enviroment conditions.




Group Members:

Wan Syamimi binti Wan Kamarul Zaman- 1000924550

Sara Razmkhah- 1000923965

Wan Nurhamiza binti Sobri- 1000924559

Monday, August 2, 2010

Food laboratory regulation

Ethical guideline for scientist/ researcher/ biotechnologist

INTRODUCTION




Ethics is concerned with the conduct of human beings. All scientific activities, including those by the social scientists, are conducted with the participation of human beings or have an impact on human beings or on the wider society and environment. Therefore, it is essential that scientists/researchers understand ethical issues and the implications of their scientific work and act accordingly. For making ethical judgement, the scientists/researchers rely upon various standards of ethics, which could be universal or specific to the culture(s) or localities. Indeed, it is essential that researchers share and discuss the ethical issues in their work and evolve collective standards of their own.  Self-regulation and ethics have been issues for debate within research more often in medicine than in social sciences. The Second World War and the Nuremberg trials of doctor-researchers exposed the horrors of the fascist politics as well as unethical biomedical research. In the post World War period, therefore, the scientists paid increased attention to ethics in biomedical research. In the process, the quality and validity of unethical research was questioned, the human rights of participants recognised and ethical codes formulated. The Nuremberg Code (1947) was followed by the Declaration of Helsinki in 1964, which was amended subsequently (WMA, 1989). The Council for International Organisations of Medical Sciences (CIOMS) and the World Health Organisation (WHO) (1993) also proposed guidelines in 1983 and adopted them in 1992. These international developments followed as well as inspired several such initiatives at the national level and in various specific fields of biomedical research. India, too, did not remain unaffected. In 1980, the Indian Council of Medical Research formulated "Policy statement on ethical considerations involved in research on human subjects" and in 1997, it brought out the draft of "Consultative Document on Ethical Guidelines on Biomedical Research Involving Human Subjects". The issue of ethics in social sciences, unlike in medical research, has been given less prominence in India. Although many social scientists have paid serious attention to the appropriate conduct of research and set personal examples, they are often not discussed as ethics and no efforts are made to formalise some guidelines based on such experience(s). Our national councils for social science research and their institutions have many guidelines either as administrative orders or for improving the quality of research but enough efforts have not been made to bring them together as comprehensive ethical guidelines. 


BACKGROUND
March 1, 1999
These ethical guidelines for biotechnology originated at the Center for Ethics and Toxics in Gualala, California with the realization that no guideposts existed for the development of the new science of biotechnology other than the rather non-specific tenets of science and medical ethics. A code or set of ethical principles serving as a guideline was needed because biotechnology has such great potential to reshape life generally and individual species particularly.  While humans have already reshaped the course of evolution during our short tenure on Earth, until now we have been powerless to intervene selectively into the genetic material of particular species. With biotechnological advances, it has proven possible to move and insert disparate genes from disparate species so that new genetic elements become permanent fixtures of the germ line of certain species.  The genes chosen to be ensconced in the descendants of such newly created transgenic animals or plants have never been chosen through open public debate, universally accepted standards, or determination of their intrinsic “good”. The shocking details of the post Second World War (1939-45) trial of German medical practitioners accused of conducting experiments on human participants without their consent and exposing them to grave risk of death or permanent impairment of their faculties raised grave concern about subjecting human subjects to medical research.
Thus, the first International Statement on the ethics of medical research using human
subjects namely, the Nuremberg Code was formulated in 1947. Although informed consent for participation in research was recorded in 1900, the Nuremberg Code highlighted the essentiality of voluntariness of this consent. In 1948, Universal Declaration of Human Rights (adopted by the General Assembly of the United
Nations) expressed concern about rights of human beings being subjected to involuntary maltreatment. In 1966, the International Covenant on Civil and Political Rights specifically stated, No one shall be subjected to torture or to cruel, inhuman or degrading treatment or punishment. In particular, no one shall be subjected without his consent to medical or scientific treatment.’ Based on the preliminary efforts of the Council for International Organisations of Medical Sciences (CIOMS) in 1964 at Helsinki, the World Medical Association formulated general principles and specific guidelines on use of human subjects in
medical research, known as the Helsinki Declaration, which was revised from
time to time. In February 1980, the Indian Council of Medical Research released a ‘Policy Statement on Ethical Considerations involved in Research on Human Subjects’ for the benefit of all those involved in clinical research in India. In 1982, the World Health Organisation (WHO) and the CIOMS issued the ‘Proposed
International Guidelines for Biomedical Research involving Human Subjects.’ Subsequently the CIOMS brought out the ‘International Guidelines for Ethical Review in Epidemiological studies’ in 1991 and ‘International Ethical Guidelines for Biomedical Research involving Human Subjects’ in 1993. The most recent documents on ethics are those of UNESCO’s “The Universal Declaration on Human Genome and Human Rights” (1997), “The International Declaration on Human Gene Data” (2003) and “Universal Declaration on Bioethics and Human Rights” (2005).

IMPORTANCE OF RESEARCH ETHICS

Designing and implementing an experimental study often requires us both to ask factual questions (“How does this disease arise? Does this drug produce a clinically important effect?”) and to make value judgements (“This intervention is likely to alter the natural course of this type of stomach cancer”, or “The unwanted effects of treatment are so severe that we should stop the trial”). As in managing ill patients, therefore, research requires not only scientific and technical knowledge, but also value judgements. These judgments need to be systemically analyzed and validated, just as with the results of experiments. So, ethics or moral philosophy is that set of rules which guides rational and good behaviour. Bioethics is that branch of ethics which deals with biomedical research, specifically with questions related to artificial reproduction, tissue transplantation and genetic engineering. Ethics cannot define absolute right or absolute wrong; even if it could, it may not be valid in all possible types of research. Also, how ethics translates into real behavior varies according to the religious, socioeconomic and political context. For this reason, I believe we ought to pay greater attention to humanist moral principles that transcend religion, while recognizing that any given community’s ethical guidelines are influenced by the legal, socioeconomic and political climate of the time.

REFERENCES

1.      Beauchamp T L, Childress J F. Principles of biomedical ethics. 4th ed. New York: Oxford University Press, 1994
2.      Dupre J. Human nature and the limits of science. Oxford: Clarendon Press, 2001
3.      Gillon R. Philosophical medical ethics. Chichester: Wiley, 1987

Group 6
Nametso Mathiba 1000921467
Amantle Diteko 1000921532
Eswari

Ethical guideline for scientist/ researcher/ biotechnologist

INTRODUCTION

Ethics is concerned with the conduct of human beings. All scientific activities, including those by the social scientists, are conducted with the participation of human beings or have an impact on human beings or on the wider society and environment. Therefore, it is essential that scientists/researchers understand ethical issues and the implications of their scientific work and act accordingly. For making ethical judgement, the scientists/researchers rely upon various standards of ethics, which could be universal or specific to the culture(s) or localities. Indeed, it is essential that researchers share and discuss the ethical issues in their work and evolve collective standards of their own.  Self-regulation and ethics have been issues for debate within research more often in medicine than in social sciences. The Second World War and the Nuremberg trials of doctor-researchers exposed the horrors of the fascist politics as well as unethical biomedical research. In the post World War period, therefore, the scientists paid increased attention to ethics in biomedical research. In the process, the quality and validity of unethical research was questioned, the human rights of participants recognised and ethical codes formulated. The Nuremberg Code (1947) was followed by the Declaration of Helsinki in 1964, which was amended subsequently (WMA, 1989). The Council for International Organisations of Medical Sciences (CIOMS) and the World Health Organisation (WHO) (1993) also proposed guidelines in 1983 and adopted them in 1992. These international developments followed as well as inspired several such initiatives at the national level and in various specific fields of biomedical research. India, too, did not remain unaffected. In 1980, the Indian Council of Medical Research formulated "Policy statement on ethical considerations involved in research on human subjects" and in 1997, it brought out the draft of "Consultative Document on Ethical Guidelines on Biomedical Research Involving Human Subjects". The issue of ethics in social sciences, unlike in medical research, has been given less prominence in India. Although many social scientists have paid serious attention to the appropriate conduct of research and set personal examples, they are often not discussed as ethics and no efforts are made to formalise some guidelines based on such experience(s). Our national councils for social science research and their institutions have many guidelines either as administrative orders or for improving the quality of research but enough efforts have not been made to bring them together as comprehensive ethical guidelines.

BACKGROUND
March 1, 1999
These ethical guidelines for biotechnology originated at the Center for Ethics and Toxics in Gualala, California with the realization that no guideposts existed for the development of the new science of biotechnology other than the rather non-specific tenets of science and medical ethics. A code or set of ethical principles serving as a guideline was needed because biotechnology has such great potential to reshape life generally and individual species particularly.  While humans have already reshaped the course of evolution during our short tenure on Earth, until now we have been powerless to intervene selectively into the genetic material of particular species. With biotechnological advances, it has proven possible to move and insert disparate genes from disparate species so that new genetic elements become permanent fixtures of the germ line of certain species.  The genes chosen to be ensconced in the descendants of such newly created transgenic animals or plants have never been chosen through open public debate, universally accepted standards, or determination of their intrinsic “good”. The shocking details of the post Second World War (1939-45) trial of German medical practitioners accused of conducting experiments on human participants without their consent and exposing them to grave risk of death or permanent impairment of their faculties raised grave concern about subjecting human subjects to medical research.
Thus, the first International Statement on the ethics of medical research using human
subjects namely, the Nuremberg Code was formulated in 1947. Although informed consent for participation in research was recorded in 1900, the Nuremberg Code highlighted the essentiality of voluntariness of this consent. In 1948, Universal Declaration of Human Rights (adopted by the General Assembly of the United
Nations) expressed concern about rights of human beings being subjected to involuntary maltreatment. In 1966, the International Covenant on Civil and Political Rights specifically stated, No one shall be subjected to torture or to cruel, inhuman or degrading treatment or punishment. In particular, no one shall be subjected without his consent to medical or scientific treatment.’ Based on the preliminary efforts of the Council for International Organisations of Medical Sciences (CIOMS) in 1964 at Helsinki, the World Medical Association formulated general principles and specific guidelines on use of human subjects in
medical research, known as the Helsinki Declaration, which was revised from
time to time. In February 1980, the Indian Council of Medical Research released a ‘Policy Statement on Ethical Considerations involved in Research on Human Subjects’ for the benefit of all those involved in clinical research in India. In 1982, the World Health Organisation (WHO) and the CIOMS issued the ‘Proposed
International Guidelines for Biomedical Research involving Human Subjects.’ Subsequently the CIOMS brought out the ‘International Guidelines for Ethical Review in Epidemiological studies’ in 1991 and ‘International Ethical Guidelines for Biomedical Research involving Human Subjects’ in 1993. The most recent documents on ethics are those of UNESCO’s “The Universal Declaration on Human Genome and Human Rights” (1997), “The International Declaration on Human Gene Data” (2003) and “Universal Declaration on Bioethics and Human Rights” (2005).

IMPORTANCE OF RESEARCH ETHICS
Designing and implementing an experimental study often requires us both to ask factual questions (“How does this disease arise? Does this drug produce a clinically important effect?”) and to make value judgements (“This intervention is likely to alter the natural course of this type of stomach cancer”, or “The unwanted effects of treatment are so severe that we should stop the trial”). As in managing ill patients, therefore, research requires not only scientific and technical knowledge, but also value judgements. These judgements need to be systemically analysed and validated, just as with the results of experiments. So, ethics or moral philosophy is that set of rules which guides rational and good behaviour. Bioethics is that branch of ethics which deals with biomedical research, specifically with questions related to artificial reproduction, tissue transplantation and genetic engineering. Ethics cannot define absolute right or absolute wrong; even if it could, it may not
be valid in all possible types of research. Also, how ethics translates into real behaviour varies according to the religious, socioeconomic and political context. For this reason, I believe we ought to pay greater attention to humanist moral principles that transcend religion, while recognising that any given community’s ethical guidelines are influenced by the legal, socioeconomic and political climate of the time.

REFERENCES

1.      Beauchamp T L, Childress J F. Principles of biomedical ethics. 4th ed. New York: Oxford University Press, 1994
2.      Dupre J. Human nature and the limits of science. Oxford: Clarendon Press, 2001
3.      Gillon R. Philosophical medical ethics. Chichester: Wiley, 1987

Group 6
Nametso Mathiba 1000921467
Amantle Diteko 1000921532
Eswari